Hull York Medical School University of Hull University of York University of Liverpool Hull University Teaching Hospital NHS Trust King's College Hospital NHS Foundation Trust

Resources

Education resources

Podcast United Kingdom

The Research Room PPI podcast

We are thrilled to share that the The Research Room PPI podcast that Mary and Kate featured in is now live!
Author: 
Country:  United Kingdom
United Kingdom

FutureLearn Course – Invasive Fungal Diseases: What the Healthcare Professional Needs to Know

Explore invasive fungal infections and gain the skills to diagnose, treat, and prevent them in your healthcare practice.
Author:  British Society for Antimicrobial Chemotherapy (BSAC), Gavin Barlow, Neil Stone, Laura Whitney and Lewis White
Country:  United Kingdom
United Kingdom

BioDriveAFS Investigators’ Day 2025

Recording of the BioDriveAFS Investigators' Day held on the 24th June 2025, 1 hours and 37 minutes
Author:  Chaired by David Allsup and Gavin Barlow
Country:  United Kingdom
United Kingdom

Haematological Malignancy Research Network (HMRN)

The Haematological Malignancy Research Network provides information about leukaemias, lymphomas, myelomas, and related blood disorders, based on data from the UK.
Author:  HMRN
Country:  United Kingdom
United Kingdom

BioDriveAFS Patient Advisory Group – Experiences

In the video, two members from the BioDriveAFS Patient Advisory Group, Kate Common and Samantha-Jane Hunt, share their experiences from diagnosis to their involvement in the BioDriveAFS trial.
Author:  Chaired by Gavin Barlow
Country:  United Kingdom
United Kingdom

Presentation for HYMS Postgraduate Research Conference

Presentation on Mycobiome in Acute Leukaemia presented by Thomas Taynton at the Hull and York Medical School (HYMS) Postgraduate Research Conference in July 2023
Author:  Thomas Taynton
Country:  United Kingdom
United Kingdom

Improving Biomarker Turnaround Time

Outline of mapping of turnaround time, and suggestions to reduce, for invasive fungal infection biomarker tests for BioDriveAFS trial
Author:  Thomas Taynton, Gavin Barlow, David Allsup
Country:  United Kingdom
United Kingdom

BioDriveAFS Investigators’ Day

Recording of the BioDriveAFS Investigators' Day held on the 6th June 2023, 3 hours and 35 minutes
Author:  Chaired by David Allsup and Gavin Barlow
Country:  United Kingdom
fungal infection United Kingdom

Treatment of Systemic Fungal Infections

Webinar, 90 minutes duration
Author:  BSAC, Chaired by Gavin Barlow
Country:  United Kingdom
Fungal diagnostics Stewardship Critically ill United Kingdom

Fungal Diagnostics in Critically Ill Patients

Open access on-line e-learning course
Author:  British Society for Antimicrobial Chemotherapy
Country:  United Kingdom

Related literature

British Society of Antimicrobial Chemotherapy United Kingdom

Pharmacy professionals should ‘seize the day’ by getting involved with the BioDrive AFS study to further their research expertise

Pharmacy professionals are urged to seize the opportunity presented by the BioDrive AFS study, engaging in antimicrobial stewardship research to advance scientific knowledge and showcase leadership in optimizing therapeutic strategies for patients undergoing intensive chemotherapy.
Author:  Andrea Hilton, Puvan Tharmanathan, Michelle Watson, Radwa Abdelatif, David Allsup, Gavin Barlow, Jacqueline Sneddon
Country:  United Kingdom
Scientific Paper Plain English Summary United Kingdom

Plain English Summary – Bloos et al. (2022) (1 → 3)‑β‑d‑Glucan‑guided antifungal therapy in adults with sepsis

Plain English Summary of (1 → 3)‑β‑d‑Glucan‑guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial
Author:  Thomas Taynton on behalf of BioDriveAFS team
Country:  United Kingdom
Scientific Paper Plain English Summary United Kingdom

Plain English Summary – Kort et al. (2022), Invasive Fungal Disease in Patients with Myeloid

Plain English Summary of Invasive Fungal Disease in Patients with Myeloid Malignancies: A Retrospective Cohort Study of a Diagnostic-Driven Care Pathway Withholding Mould-Active Prophylaxis
Author:  Thomas Taynton on behalf of BioDriveAFS team
Country:  United Kingdom
Scientific Paper Plain English Summary United Kingdom

Plain English Summary – Maertens et al. (2021), Posaconazole versus voriconazole for primary treatment of invasive aspergillosis

Plain English Summary of Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial
Author:  Thomas Taynton on behalf of BioDriveAFS team
Country:  United Kingdom
Scientific Paper Plain English Summary United Kingdom

Plain English Summary – Maertens et al. (2022), Empiric vs Preemptive Antifungal Strategy in High-Risk Neutropenic Patients on Fluconazole Prophylaxis

Plain english summary of Empiric vs Preemptive Antifungal Strategy in High-Risk Neutropenic Patients on Fluconazole Prophylaxis: A Randomized Trial of the European Organization for Research and Treatment of Cancer
Author:  Thomas Taynton on behalf of BioDriveAFS team
Country:  United Kingdom
Scientific Paper Plain English Summary United Kingdom

Plain English Summary – Stemler et al. (2022) Antifungal prophylaxis in adult patients with acute myeloid leukaemia treated with novel targeted therapies

Plain English Summary of Antifungal prophylaxis in adult patients with acute myeloid leukaemia treated with novel targeted therapies: a systematic review and expert consensus recommendation from the European Hematology Association
Author:  Thomas Taynton on behalf of BioDriveAFS team
Country:  United Kingdom
Scientific Paper United Kingdom

Should serum biomarker monitoring replace primary antifungal chemoprophylaxis in patients with acute leukaemia receiving systemic anti-cancer therapy?

Should serum biomarker monitoring replace primary antifungal chemoprophylaxis in patients with acute leukaemia receiving systemic anti-cancer therapy? A PRO/CON debate. Published in the Journal of Antimicrobial Chemotherapy. Authors Thomas Harrison and David Partridge
Author:  Thomas Harrison, David Partridge
Country:  United Kingdom
Scientific Paper United Kingdom

CON: Serum biomarker monitoring should not replace primary antifungal chemoprophylaxis

CON: Serum biomarker monitoring should not replace primary antifungal chemoprophylaxis in patients with acute leukaemia receiving systemic anti-cancer therapy published in the Journal of of Antimicrobial Chemotherapy. Authors Alex Howard and William Hope (BioDriveAFS Trial Management Group Members)
Author:  Alex Howard, William Hope
Country:  United Kingdom
Scientific Paper United Kingdom

PRO: Biomarker surveillance for invasive fungal infections

PRO: Biomarker surveillance for invasive fungal infections without antifungal prophylaxis could safely reduce antifungal use in acute leukaemia published in the Journal of of Antimicrobial Chemotherapy. Authors Thomas Taynton (Clinical Research Fellow), Gavin Barlow (Co-CI of BioDriveAFS) and David Allsup (Co-CI of BioDriveAFS)
Author:  Thomas Taynton, Gavin Barlow, David Allsup
Country:  United Kingdom

Resources for site staff

United Kingdom

Intrevention Arm Flow Chart

Flow chart to guide decision making for patients in the intrevention arm of the BioDriveAFS Trial
Author:  Thomas Taynton, Gavin Barlow, David Allsup
Country:  United Kingdom
United Kingdom

Trial Protocol

BioDriveAFS Trial Protocol_v2.5 14.01.2025
Author:  BioDriveAFS Team
Country:  United Kingdom

Trial impact and engagement

United Kingdom

The Research Room Podcast – BioDriveAFS Episode

BioDriveAFS team members Professor David Allsup (Co-Chief Investigator) and Lydia Flett (Trial Manager) sat down with the hosts of the York Trials Unit Podcast, 'The Research Room' to record an episode all about the BioDriveAFS trial.
Author:  The Research Room, David Allsup, Lydia Flett
Country:  United Kingdom
United Kingdom

BioDriveAFS Investigators’ Day 2025

Recording of the BioDriveAFS Investigators' Day held on the 24th June 2025, 1 hours and 37 minutes
Author:  Chaired by David Allsup and Gavin Barlow
Country:  United Kingdom
Trials BioDriveAFS United Kingdom

Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute leukaemia—a multi-centre randomised controlled trial to assess clinical and cost efectiveness: a study protocol for a randomised controlled trial

Protocol Paper
Author:  Lydia Flett, Radwa Abdelatif, Sarah Akhtar Baz, Samantha Brady, Belén Corbacho, Kate Common, Abbie Cowling, Caroline Fairhurst, Ellie Fitzmaurice, Shreyans Gandhi, Andrea Hilton, William Hope, Alex Howard, Joanne Laycock, Patrick Lillie, Gemma Mitchell, Adwoa Parker, Mary Peel, Laura Sheard, Jacqueline Sneddon, Thomas Taynton, Puvan Tharmanathan, David Torgerson, Han‑I Wang, David Allsup and Gavin Barlow
Country:  United Kingdom
British Society of Antimicrobial Chemotherapy United Kingdom

Pharmacy professionals should ‘seize the day’ by getting involved with the BioDrive AFS study to further their research expertise

Pharmacy professionals are urged to seize the opportunity presented by the BioDrive AFS study, engaging in antimicrobial stewardship research to advance scientific knowledge and showcase leadership in optimizing therapeutic strategies for patients undergoing intensive chemotherapy.
Author:  Andrea Hilton, Puvan Tharmanathan, Michelle Watson, Radwa Abdelatif, David Allsup, Gavin Barlow, Jacqueline Sneddon
Country:  United Kingdom
United Kingdom

BioDriveAFS Patient Advisory Group – Experiences

In the video, two members from the BioDriveAFS Patient Advisory Group, Kate Common and Samantha-Jane Hunt, share their experiences from diagnosis to their involvement in the BioDriveAFS trial.
Author:  Chaired by Gavin Barlow
Country:  United Kingdom
United Kingdom

Presentation for HYMS Postgraduate Research Conference

Presentation on Mycobiome in Acute Leukaemia presented by Thomas Taynton at the Hull and York Medical School (HYMS) Postgraduate Research Conference in July 2023
Author:  Thomas Taynton
Country:  United Kingdom
United Kingdom

BioDriveAFS Investigators’ Day

Recording of the BioDriveAFS Investigators' Day held on the 6th June 2023, 3 hours and 35 minutes
Author:  Chaired by David Allsup and Gavin Barlow
Country:  United Kingdom
Scientific Paper United Kingdom

Should serum biomarker monitoring replace primary antifungal chemoprophylaxis in patients with acute leukaemia receiving systemic anti-cancer therapy?

Should serum biomarker monitoring replace primary antifungal chemoprophylaxis in patients with acute leukaemia receiving systemic anti-cancer therapy? A PRO/CON debate. Published in the Journal of Antimicrobial Chemotherapy. Authors Thomas Harrison and David Partridge
Author:  Thomas Harrison, David Partridge
Country:  United Kingdom
Scientific Paper United Kingdom

CON: Serum biomarker monitoring should not replace primary antifungal chemoprophylaxis

CON: Serum biomarker monitoring should not replace primary antifungal chemoprophylaxis in patients with acute leukaemia receiving systemic anti-cancer therapy published in the Journal of of Antimicrobial Chemotherapy. Authors Alex Howard and William Hope (BioDriveAFS Trial Management Group Members)
Author:  Alex Howard, William Hope
Country:  United Kingdom
Scientific Paper United Kingdom

PRO: Biomarker surveillance for invasive fungal infections

PRO: Biomarker surveillance for invasive fungal infections without antifungal prophylaxis could safely reduce antifungal use in acute leukaemia published in the Journal of of Antimicrobial Chemotherapy. Authors Thomas Taynton (Clinical Research Fellow), Gavin Barlow (Co-CI of BioDriveAFS) and David Allsup (Co-CI of BioDriveAFS)
Author:  Thomas Taynton, Gavin Barlow, David Allsup
Country:  United Kingdom